RHOD è un gene codificato dal simbolo RHOD. È noto anche come: Rho-related GTP-binding protein Rho-related protein HP1; RhoHP1; ARHD. RHOD ha una massa di 23.41kDa e una lunghezza di amminoacidi di 210.
Offriamo 7 anticorpi contro RHOD, allevati nel Coniglio, che sono adatti per WB, IHC, ELISA, ICC/IF e IP con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution.
Sommario di Entrez
Ras homolog, or Rho, proteins interact with protein kinases and may serve as targets for activated GTPase. They play a critical role in muscle differentiation. The protein encoded by this gene binds GTP and is a member of the small GTPase superfamily. It is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton. Two transcript variants encoding different isoforms have been found for this gene.
Specificità del tessuto
Heart, placenta, liver, skeletal muscle, and pancreas and, with weaker intensity, in several other tissues.
Somiglianze di sequenza
Belongs to the small GTPase superfamily. Rho family.
Posizione cellulare
Cell membrane. Early endosome.
Colocalizes with RAB5 to early endosomes (By similarity).
