RHEB è un gene codificato dal simbolo RHEB. È noto anche come GTP-binding protein Ras homolog enriched in brain2. RHEB ha una massa di 20.5kDa e una lunghezza di amminoacidi di 184.
Offriamo 7 anticorpi contro RHEB, allevati nel Coniglio, che sono adatti per WB, IHC e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity.
Sommario di Entrez
This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22.
Specificità del tessuto
Ubiquitous. Highest levels observed in skeletal and cardiac muscle.
Somiglianze di sequenza
Belongs to the small GTPase superfamily. Rheb family.
Modifica post-translazionale
Farnesylation is important for efficiently activating mTORC1-mediated signaling.
Posizione cellulare
Endomembrane system. Golgi apparatus membrane. Cytoplasm > Cytosol. Endoplasmic reticulum membrane.
