Resistin è un gene codificato dal simbolo RETN. È noto anche come: Adipose tissue-specific secretory factor; ADSF; C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein; Cysteine-rich secreted protein A12-alpha-like 2; Cysteine-rich secreted protein FIZZ3; RETN; FIZZ3; HXCP1; RSTN. Resistin ha una massa di 11.42kDa e una lunghezza di amminoacidi di 108.
Offriamo 19 anticorpi contro Resistin, allevati nel Coniglio, Topo, Capra e Pollo, che sono adatti per WB, IHC e ELISA con campioni derivati da Umano.
Informazioni su geni e proteine
Riepilogo UniProt
Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells (By similarity). Potentially links obesity to diabetes (By similarity). Promotes chemotaxis in myeloid cells (PubMed:15064728).
Sommario di Entrez
This gene belongs to the family defined by the mouse resistin-like genes. The characteristic feature of this family is the C-terminal stretch of 10 cys residues with identical spacing. The mouse homolog of this protein is secreted by adipocytes, and may be the hormone potentially linking obesity to type II diabetes. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
Specificità del tessuto
Expressed in white adipose tissue (at protein level) (PubMed:11201732). Widely expressed, with particularly strong expression in lung, bone marrow, breast and peripheral blood (PubMed:15248836). Expressed strongly in bone marrow and at lower levels in lung, but not detected in other tissues (PubMed:15064728). Isoform 2 is detected in adipose tissue, bone marrow, brain, lung, peripheral blood, placenta and thymus (PubMed:15248836).
Somiglianze di sequenza
Belongs to the resistin/FIZZ family.
Posizione cellulare
Secreted.
