Renalase è un gene codificato dal simbolo RNLS. È noto anche come: Monoamine oxidase-C; MAO-C; RNLS; C10orf59. Renalase ha una massa di 37.85kDa e una lunghezza di amminoacidi di 342.
Offriamo 6 anticorpi contro Renalase, allevati nel Coniglio, Topo e Capra, che sono adatti per WB e ELISA con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis.
Sommario di Entrez
Renalase is a flavin adenine dinucleotide-dependent amine oxidase that is secreted into the blood from the kidney (Xu et al., 2005
Specificità del tessuto
Secreted into the blood by the kidney. Highly expressed in the kidney, expressed at lower level in heart, skeletal muscle and small intestine. Its plasma concentration is markedly reduced in patients with end-stage renal disease, as compared with healthy subjects.
Somiglianze di sequenza
Belongs to the renalase family.
Posizione cellulare
Secreted.
