RALB è un gene codificato dal simbolo RALB. È noto anche come Ras-related protein Ral-B. RALB ha una massa di 23.41kDa e una lunghezza di amminoacidi di 206.
Offriamo 9 anticorpi contro RALB, allevati nel Coniglio e Topo, che sono adatti per WB, IHC e ICC/IF con campioni derivati da Umano, Topo, Ratto, Scimmia e Cane.
Informazioni su geni e proteine
Riepilogo UniProt
Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity). Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity). Required for suppression of apoptosis (PubMed:17875936). In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission (PubMed:18756269).
Sommario di Entrez
This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors.
Somiglianze di sequenza
Belongs to the small GTPase superfamily. Ras family.
Modifica post-translazionale
Prenylation is essential for membrane localization. The geranylgeranylated form and the farnesylated mutant does not undergo alternative prenylation in response to geranylgeranyltransferase I inhibitors (GGTIs) and farnesyltransferase I inhibitors (FTIs).
Posizione cellulare
Cell membrane. Midbody.
During late cytokinesis, enriched at the midbody.
