Radixin è un gene codificato dal simbolo RDX. È noto anche come RDX. Radixin ha una massa di 68.56kDa, una lunghezza di amminoacidi di 583, ed è implicato in Deafness, autosomal recessive, 24.
Offriamo 6 anticorpi contro Radixin, allevati nel Coniglio e Capra, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane.
Sommario di Entrez
Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Coinvolgimento nella malattia
Deafness, autosomal recessive, 24: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Modifica post-translazionale
Phosphorylated by tyrosine-protein kinases. Phosphorylation by ROCK2 suppresses the head-to-tail association of the N-terminal and C-terminal halves resulting in an opened conformation which is capable of actin and membrane-binding (By similarity).
Posizione cellulare
Cell membrane. Cytoplasm > Cytoskeleton. Cleavage furrow. Cell projection > Microvillus.
Highly concentrated in the undercoat of the cell-to-cell adherens junction and the cleavage furrow in the interphase and mitotic phase, respectively.
