RAD52 è un gene codificato dal simbolo RAD52. È noto anche come DNA repair protein RAD52 homolog. RAD52 ha una massa di 46.17kDa e una lunghezza di amminoacidi di 418.
Offriamo 9 anticorpi contro RAD52, allevati nel Coniglio, che sono adatti per WB, IHC, ELISA, ICC/IF e IP con campioni derivati da Umano, Topo, Ratto e Criceto.
Informazioni su geni e proteine
Riepilogo UniProt
Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase.
Sommario di Entrez
The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51 related DNA recombination and repair. A pseudogene of this gene is present on chromosome 2. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
Somiglianze di sequenza
Belongs to the RAD52 family.
Modifica post-translazionale
Phosphorylated upon DNA damage by ABL1, and probably by ATM or ATR.
Posizione cellulare
Nucleus.
