Anticorpi RAC2

7 prodotti

RAC2 è un gene codificato dal simbolo RAC2. È noto anche come: Ras-related C3 botulinum toxin substrate 2; GX; Small G protein; p21-RAC2. RAC2 ha una massa di 21.43kDa, una lunghezza di amminoacidi di 192, ed è implicato in Neutrophil immunodeficiency syndrome.

Offriamo 7 anticorpi contro RAC2, allevati nel Coniglio, Topo e Capra, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati ​​da Umano, Topo e Ratto.

Informazioni su geni e proteine

Riepilogo UniProt
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase.
Sommario di Entrez
This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarization. Activity of this protein is also involved in the generation of reactive oxygen species. Mutations in this gene are associated with neutrophil immunodeficiency syndrome. There is a pseudogene for this gene on chromosome 6.
Specificità del tessuto
Hematopoietic specific.
Coinvolgimento nella malattia
Neutrophil immunodeficiency syndrome: An immunodeficiency syndrome due to defective neutrophils. Affected individuals present with leukocytosis, neutrophilia, severe recurrent bacterial infections and poor wound healing.
Somiglianze di sequenza
Belongs to the small GTPase superfamily. Rho family.
Modifica post-translazionale
(Microbial infection) Glycosylated at Tyr-32 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rac and leads to actin disassembly.
Posizione cellulare
Cytoplasm.

Membrane-associated when activated.
Collegamenti al database
Western Blot - Anti-RAC2 Antibody (A13303) - Antibodies.com
(5)
Western Blot - Anti-RAC2 Antibody (A83810) - Antibodies.com
(2)
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Anti-RAC2 Antibody from Bioworld Technology (BS6170) - Antibodies.com
RAC2 Antibody from Signalway Antibody (43907) - Antibodies.com
(2)
Anti-RAC2 Antibody from Bioworld Technology (BS60217) - Antibodies.com
Western blot - RAC2 antibody from Signalway Antibody (38201) - Antibodies.com

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