RAB6A è un gene codificato dal simbolo RAB6A. È noto anche come: Ras-related protein Rab-6A; Rab-6; RAB6. RAB6A ha una massa di 23.59kDa e una lunghezza di amminoacidi di 208.
Offriamo 7 anticorpi contro RAB6A, allevati nel Coniglio, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. Involved in COPI-independent retrograde transport from the Golgi to the ER (PubMed:25962623).
Sommario di Entrez
This gene encodes a member of the RAB family, which belongs to the small GTPase superfamily. GTPases of the RAB family bind to various effectors to regulate the targeting and fusion of transport carriers to acceptor compartments. This protein is located at the Golgi apparatus, which regulates trafficking in both a retrograde (from early endosomes and Golgi to the endoplasmic reticulum) and an anterograde (from the Golgi to the plasma membrane) directions. Myosin II is an effector of this protein in these processes. This protein is also involved in assembly of human cytomegalovirus (HCMV) by interacting with the cellular protein Bicaudal D1, which interacts with the HCMV virion tegument protein, pp150. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Specificità del tessuto
Ubiquitous.
Somiglianze di sequenza
Belongs to the small GTPase superfamily. Rab family.
Modifica post-translazionale
Prenylated.
Posizione cellulare
Golgi apparatus membrane.
BICD2 facilitates its targeting to Golgi apparatus membrane.
