PUMA è un gene codificato dal simbolo BBC3. Comunemente indicato anche come: Bcl-2-binding component 3, isoforms 1/2; JFY-1; p53 up-regulated modulator of apoptosis; BBC3. PUMA ha una massa di 20.53kDa e una lunghezza di amminoacidi di 193.
Offriamo 16 anticorpi contro PUMA, allevati nel Coniglio, Topo e Capra, che sono adatti per WB, IHC, ELISA, ICC/IF e Citometria a Flusso con campioni derivati da Umano, Topo, Ratto e Pollo.
Informazioni su geni e proteine
Riepilogo UniProt
Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis (PubMed:11463391). Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Regulates ER stress-induced neuronal apoptosis (PubMed:23340338).
Sommario di Entrez
This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants.
Specificità del tessuto
Ubiquitously expressed.
Somiglianze di sequenza
Belongs to the Bcl-2 family.
Posizione cellulare
Mitochondrion.
Localized to the mitochondria in order to induce cytochrome c release.
