PRDM14 è un gene codificato dal simbolo PRDM14. Comunemente indicato anche come: PR domain zinc finger protein 14; PR domain-containing protein 14. PRDM14 ha una massa di 64.06kDa e una lunghezza di amminoacidi di 571.
Offriamo 10 anticorpi contro PRDM14, allevati nel Coniglio e Capra, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso, IP e ChIP con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of embryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation (By similarity). Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA-3'.
Sommario di Entrez
This gene encodes a member of the PRDI-BF1 and RIZ homology domain containing (PRDM) family of transcriptional regulators. The encoded protein may possess histone methyltransferase activity and plays a critical role in cell pluripotency by suppressing the expression of differentiation marker genes. Expression of this gene may play a role in breast cancer.
Specificità del tessuto
Expressed in embryonic stem cells. Tends to be overexpressed in breast cancer (at protein level).
Somiglianze di sequenza
Belongs to the class V-like SAM-binding methyltransferase superfamily.
Posizione cellulare
Nucleus.
