PRAME è un gene codificato dal simbolo PRAME. Comunemente indicato anche come: Melanoma antigen preferentially expressed in tumors; Opa-interacting protein 4; OIP-4; Preferentially expressed antigen of melanoma; MAPE; OIP4. PRAME ha una massa di 57.89kDa e una lunghezza di amminoacidi di 509.
Offriamo 10 anticorpi contro PRAME, allevati nel Coniglio e Human, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis.
Sommario di Entrez
This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants.
Specificità del tessuto
Expressed in testis. Detected in samples of kidney, brain and skin.
Somiglianze di sequenza
Belongs to the PRAME family.
Posizione cellulare
Nucleus. Cell membrane.
