PON2 è un gene codificato dal simbolo PON2. Comunemente indicato anche come: Serum paraoxonase/arylesterase 2; PON 2; Aromatic esterase 2; A-esterase 2; Serum aryldialkylphosphatase 2. PON2 ha una massa di 39.38kDa e una lunghezza di amminoacidi di 354.
Offriamo 8 anticorpi contro PON2, allevati nel Coniglio e Capra, che sono adatti per WB, IHC e ELISA con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis.
Sommario di Entrez
This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described.
Specificità del tessuto
Widely expressed with highest expression in liver, lung, placenta, testis and heart.
Somiglianze di sequenza
Belongs to the paraoxonase family.
Modifica post-translazionale
The signal sequence is not cleaved.
Posizione cellulare
Membrane.
