Plasma Kallikrein 1B è un gene codificato dal simbolo KLKB1. Comunemente indicato anche come: Plasma kallikrein; Fletcher factor; Kininogenin; Plasma prekallikrein; PKK; KLKB1; KLK3. Plasma Kallikrein 1B ha una massa di 71.37kDa, una lunghezza di amminoacidi di 638, ed è implicato in Prekallikrein deficiency.
Offriamo 6 anticorpi contro Plasma Kallikrein 1B, allevati nel Coniglio e Capra, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
Sommario di Entrez
This gene encodes a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. The encoded preproprotein present in plasma as a non-covalent complex with high molecular weight kininogen undergoes proteolytic processing mediated by activated coagulation factor XII to generate a disulfide-linked, heterodimeric serine protease comprised of heavy and light chains. Certain mutations in this gene cause prekallikrein deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms.
Coinvolgimento nella malattia
Prekallikrein deficiency: This disorder is a blood coagulation defect.
Somiglianze di sequenza
Belongs to the peptidase S1 family. Plasma kallikrein subfamily.
Posizione cellulare
Secreted.