PLA2G1B è un gene codificato dal simbolo PLA2G1B. Comunemente indicato anche come: Phospholipase A2; Group IB phospholipase A2; Phosphatidylcholine 2-acylhydrolase 1B; PLA2; PLA2A; PPLA2. PLA2G1B ha una massa di 16.36kDa e una lunghezza di amminoacidi di 148.
Offriamo 7 anticorpi contro PLA2G1B, allevati nel Coniglio, Capra e Human, che sono adatti per WB, IHC, ELISA, ICC/IF, IP e Dot con campioni derivati da Umano, Topo, Ratto e Maiale.
Informazioni su geni e proteine
Riepilogo UniProt
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules.
Sommario di Entrez
This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response.
Somiglianze di sequenza
Belongs to the phospholipase A2 family.
Modifica post-translazionale
Activated by trypsin cleavage in the duodenum. Can also be activated by thrombin or autocatalytically.
Posizione cellulare
Secreted.
secreted from pancreatic acinar cells in its inactive form.
