PIAS3 è un gene codificato dal simbolo PIAS3. È noto anche come E3 SUMO-protein ligase E3 SUMO-protein transferase Protein inhibitor of activated STAT protein 3. PIAS3 ha una massa di 68.02kDa e una lunghezza di amminoacidi di 628.
Offriamo 8 anticorpi contro PIAS3, allevati nel Coniglio, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678, PubMed:9388184). Sumoylates CCAR2 which promotes its interaction with SIRT1 (PubMed:25406032). Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (PubMed:24651376).
Sommario di Entrez
This gene encodes a member of the PIAS
Specificità del tessuto
Widely expressed.
Somiglianze di sequenza
Belongs to the PIAS family.
Modifica post-translazionale
Sumoylated.
Posizione cellulare
Cytoplasm. Nucleus. Nucleus speckle.
Colocalizes with MITF in the nucleus. Colocalizes with GFI1 in nuclear dots. Colocalizes with SUMO1 in nuclear granules.
