PI 3 Kinase Class 3 è un gene codificato dal simbolo PIK3C3. Comunemente indicato anche come: Phosphatidylinositol 3-kinase catalytic subunit type 3; PI3-kinase type 3; Phosphatidylinositol 3-kinase p100 subunit; Phosphoinositide-3-kinase class 3; hVps34; PIK3C3; VPS34. PI 3 Kinase Class 3 ha una massa di 101.55kDa e una lunghezza di amminoacidi di 887.
Offriamo 6 anticorpi contro PI 3 Kinase Class 3, allevati nel Coniglio, che sono adatti per WB, IHC, ICC/IF e IP con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530). Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes (By similarity).
Specificità del tessuto
Ubiquitously expressed, with a highest expression in skeletal muscle.
Somiglianze di sequenza
Belongs to the PI3/PI4-kinase family.
Posizione cellulare
Midbody. Late endosome. Cytoplasmic vesicle > Autophagosome.
As component of the PI3K complex I localized to pre-autophagosome structures. As component of the PI3K complex II localized predominantly to endosomes (Probable). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity).
