PFKP è un gene codificato dal simbolo PFKP. Comunemente indicato anche come: ATP-dependent 6-phosphofructokinase, platelet type; ATP-PFK; 6-phosphofructokinase type C; Phosphofructo-1-kinase isozyme C; PFK-C; Phosphohexokinase; PFKF. PFKP ha una massa di 85.6kDa e una lunghezza di amminoacidi di 784.
Offriamo 9 anticorpi contro PFKP, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA, ICC/IF e Citometria a Flusso con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
Sommario di Entrez
This gene encodes a member of the phosphofructokinase A protein family. The encoded enzyme is the platelet-specific isoform of phosphofructokinase and plays a key role in glycolysis regulation. This gene may play a role in metabolic reprogramming in some cancers, including clear cell renal cell carcinomas, and cancer of the bladder, breast, and lung. Alternative splicing results in multiple transcript variants.
Somiglianze di sequenza
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
Modifica post-translazionale
GlcNAcylation decreases enzyme activity.
Posizione cellulare
Cytoplasm.
