PFKFB4 è un gene codificato dal simbolo PFKFB2. Comunemente indicato anche come: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2; 6PF-2-K/Fru-2,6-P2ase 2; 6PF-2-K/Fru-2,6-P2ase heart-type isozyme; PFKFB2. PFKFB4 ha una massa di 58.48kDa e una lunghezza di amminoacidi di 505.
Offriamo 7 anticorpi contro PFKFB4, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Synthesis and degradation of fructose 2,6-bisphosphate.
Sommario di Entrez
This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene.
Specificità del tessuto
Heart.
Somiglianze di sequenza
In the C-terminal section; belongs to the phosphoglycerate mutase family.
Modifica post-translazionale
Phosphorylation by AMPK stimulates activity.
