PDLIM5 è un gene codificato dal simbolo PDLIM5. Comunemente indicato anche come: PDZ and LIM domain protein 5; Enigma homolog; Enigma-like PDZ and LIM domains protein; ENH. PDLIM5 ha una massa di 63.95kDa e una lunghezza di amminoacidi di 596.
Offriamo 6 anticorpi contro PDLIM5, allevati nel Coniglio, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May restrain postsynaptic growth of excitatory synapses (By similarity).
Sommario di Entrez
This gene encodes a member of a family of proteins that possess a 100-amino acid PDZ domain at the N terminus and one to three LIM domains at the C-terminus. This family member functions as a scaffold protein that tethers protein kinases to the Z-disk in striated muscles. It is thought to function in cardiomyocyte expansion and in restraining postsynaptic growth of excitatory synapses. Alternative splicing of this gene results in multiple transcript variants.
Specificità del tessuto
Heart and skeletal muscle specific. Expression is commonly increased in the brain of patients with bipolar disorder, schizophrenia, and major depression.
Posizione cellulare
Cell junction > Synapse > Postsynaptic density. Cell junction > Synapse > Presynapse. Cell junction > Synapse > Postsynapse. Cytoplasm > Cytosol.
Detected both at presynaptic and postsynaptic sites, exclusively at excitatory synapses, but not inhibitory synapses, in hippocampal neurons.
