PDE4B è un gene codificato dal simbolo PDE4B. Comunemente indicato anche come: cAMP-specific 3',5'-cyclic phosphodiesterase 4B; DPDE4; PDE32. PDE4B ha una massa di 83.34kDa e una lunghezza di amminoacidi di 736.
Offriamo 10 anticorpi contro PDE4B, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso e IP con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.
Sommario di Entrez
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms.
Specificità del tessuto
Expressed in brain, heart, lung and skeletal muscle.
Somiglianze di sequenza
Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
