PDE10A è un gene codificato dal simbolo PDE10A. È noto anche come cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A. PDE10A ha una massa di 88.41kDa, una lunghezza di amminoacidi di 779, ed è implicato nella malattia: Dyskinesia, limb and orofacial, infantile-onset; Striatal degeneration, autosomal dominant 2.
Offriamo 10 anticorpi contro PDE10A, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso e IP con campioni derivati da Umano, Topo, Ratto e Scimmia.
Informazioni su geni e proteine
Riepilogo UniProt
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition.
Sommario di Entrez
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene.
Specificità del tessuto
Abundant in the putamen and caudate nucleus regions of brain and testis, moderately expressed in the thyroid gland, pituitary gland, thalamus and cerebellum.
Coinvolgimento nella malattia
Dyskinesia, limb and orofacial, infantile-onset: An autosomal recessive, early-onset hyperkinetic movement disorder characterized by axial hypotonia, dyskinesia of the limbs and trunk, orofacial dyskinesia, drooling, and dysarthria. The severity of the hyperkinesis is variable.
Striatal degeneration, autosomal dominant 2: An autosomal dominant disorder characterized by striatal degeneration and dysfunction of basal ganglia, resulting in hyperkinesis.
Somiglianze di sequenza
Belongs to the cyclic nucleotide phosphodiesterase family.
Modifica post-translazionale
Phosphorylated on Thr-16.
Posizione cellulare
Cytoplasm.
Located mostly to soluble cellular fractions.
