Pannexin 1 è un gene codificato dal simbolo PANX1. Comunemente indicato anche come: Pannexin-1; PANX1; MRS1. Pannexin 1 ha una massa di 48.05kDa, una lunghezza di amminoacidi di 426, ed è implicato in Oocyte maturation defect 7.
Offriamo 9 anticorpi contro Pannexin 1, allevati nel Coniglio, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Structural component of the gap junctions and the hemichannels involved in the ATP release and nucleotide permeation (PubMed:16908669, PubMed:20829356, PubMed:30918116). May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis (PubMed:16908669). Plays a critical role in oogenesis (PubMed:30918116).
Sommario di Entrez
The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties.
Specificità del tessuto
Widely expressed (PubMed:30918116). Highest expression is observed in oocytes and brain (PubMed:30918116). Detected at very low levels in sperm cells (PubMed:30918116).
Coinvolgimento nella malattia
Oocyte maturation defect 7: An autosomal dominant infertility disorder due to oocyte degeneration and death, which may occur before or after fertilization.
Somiglianze di sequenza
Belongs to the pannexin family.
Modifica post-translazionale
S-nitrosylation inhibits channel currents and ATP release.
Posizione cellulare
Cell membrane. Cell junction > Gap junction. Endoplasmic reticulum membrane.
