P70 S6 Kinase beta è un gene codificato dal simbolo RPS6KB2. Comunemente indicato anche come: Ribosomal protein S6 kinase beta-2; S6K-beta-2; 70 kDa ribosomal protein S6 kinase 2; P70S6K2; S6 kinase-related kinase; SRK; Serine/threonine-protein kinase 14B; p70 ribosomal S6 kinase beta; S6K-beta; RPS6KB2; STK14B. P70 S6 Kinase beta ha una massa di 53.46kDa e una lunghezza di amminoacidi di 482.
Offriamo 7 anticorpi contro P70 S6 Kinase beta, allevati nel Coniglio, che sono adatti per WB, IHC e ELISA con campioni derivati da Umano e Topo.
Informazioni su geni e proteine
Riepilogo UniProt
Phosphorylates specifically ribosomal protein S6 (PubMed:29750193). Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7 (PubMed:29750193).
Sommario di Entrez
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains a kinase catalytic domain and phosphorylates the S6 ribosomal protein and eukaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation.
Somiglianze di sequenza
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
Modifica post-translazionale
Phosphorylated and activated by MTOR. Phosphorylation by PKC within the NLS in response to mitogenic stimuli causes cytoplasmic retention.
Posizione cellulare
Cytoplasm. Nucleus.
