Osteocalcin è un gene codificato dal simbolo BGLAP. Comunemente indicato anche come: Bone Gla protein; BGP; Gamma-carboxyglutamic acid-containing protein; BGLAP. Osteocalcin ha una massa di 10.96kDa e una lunghezza di amminoacidi di 100.
Offriamo 16 anticorpi contro Osteocalcin, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA, ICC/IF, IP e RIA con campioni derivati da Umano, Topo, Ratto, Bovino, Maiale, Coniglio, Scimmia, Pecora, Pollo, Cane e Goat.
Informazioni su geni e proteine
Riepilogo UniProt
Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.
Sommario di Entrez
This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product.
Somiglianze di sequenza
Belongs to the osteocalcin/matrix Gla protein family.
Modifica post-translazionale
Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
Posizione cellulare
Secreted.
