Ornithine Decarboxylase è un gene codificato dal simbolo ODC1. Comunemente indicato anche come: ODC; ODC1. Ornithine Decarboxylase ha una massa di 51.15kDa e una lunghezza di amminoacidi di 461.
Offriamo 17 anticorpi contro Ornithine Decarboxylase, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA, ICC/IF e Citometria a Flusso con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
Sommario di Entrez
This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified.
Somiglianze di sequenza
Belongs to the Orn/Lys/Arg decarboxylase class-II family.
Modifica post-translazionale
S-Nitrosylation inhibits the enzyme. S-Nitrosylated in vitro on 4 cysteine residues.
