Oligodendrocyte Specific Protein è un gene codificato dal simbolo CLDN11. Comunemente indicato anche come: Claudin-11; Oligodendrocyte-specific protein; CLDN11; OSP; OTM. Oligodendrocyte Specific Protein ha una massa di 21.99kDa e una lunghezza di amminoacidi di 207.
Offriamo 6 anticorpi contro Oligodendrocyte Specific Protein, allevati nel Coniglio, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Sommario di Entrez
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.
Somiglianze di sequenza
Belongs to the claudin family.
Posizione cellulare
Cell junction > Tight junction. Cell membrane.
