Oct-2 è un gene codificato dal simbolo POU2F2. Comunemente indicato anche come: POU domain, class 2, transcription factor 2; Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2; Octamer-binding protein 2; Octamer-binding transcription factor 2; OTF-2; POU2F2; OCT2; OTF2. Oct-2 ha una massa di 51.21kDa e una lunghezza di amminoacidi di 479.
Offriamo 11 anticorpi contro Oct-2, allevati nel Coniglio, Topo e Capra, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano e Topo.
Informazioni su geni e proteine
Riepilogo UniProt
Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter.
Sommario di Entrez
The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this gene.
Specificità del tessuto
Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the immunoglobulin-expressing T-cell line MOLT-4, but not in the T-cell line BW5147.
Somiglianze di sequenza
Belongs to the POU transcription factor family. Class-2 subfamily.
Posizione cellulare
Cytoplasm. Nucleus.
