Nurr1 è un gene codificato dal simbolo NR4A2. Comunemente indicato anche come: Nuclear receptor subfamily 4 group A member 2; Immediate-early response protein NOT; Orphan nuclear receptor Transcriptionally-inducible nuclear receptor; NR4A2; NOT; TINUR. Nurr1 ha una massa di 66.59kDa e una lunghezza di amminoacidi di 598.
Offriamo 6 anticorpi contro Nurr1, allevati nel Coniglio, che sono adatti per WB, IHC, ELISA e IP con campioni derivati da Umano e Topo.
Informazioni su geni e proteine
Riepilogo UniProt
Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity).
Sommario di Entrez
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
Specificità del tessuto
Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in brain tissue.
Somiglianze di sequenza
Belongs to the nuclear hormone receptor family. NR4 subfamily.
Posizione cellulare
Cytoplasm. Nucleus.
Mostly nuclear; oxidative stress promotes cytoplasmic localization.
