Nucleostemin è un gene codificato dal simbolo GNL3. Comunemente indicato anche come: Guanine nucleotide-binding protein-like 3; E2-induced gene 3 protein; Novel nucleolar protein 47; NNP47; Nucleolar GTP-binding protein 3; GNL3; E2IG3; NS. Nucleostemin ha una massa di 61.99kDa e una lunghezza di amminoacidi di 549.
Offriamo 7 anticorpi contro Nucleostemin, allevati nel Coniglio e Capra, che sono adatti per WB, IHC, ELISA, ICC/IF e IP con campioni derivati da Umano.
Informazioni su geni e proteine
Riepilogo UniProt
May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity).
Sommario di Entrez
The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene.
Specificità del tessuto
Increased levels in lung tissue in cancer patients.
Somiglianze di sequenza
Belongs to the TRAFAC class YlqF/YawG GTPase family.
Posizione cellulare
Nucleus. Nucleus > Nucleolus.
Shuttles between the nucleus and nucleolus.
