NRF1 è un gene codificato dal simbolo NRF1. Comunemente indicato anche come: Nuclear respiratory factor 1; NRF-1; Alpha palindromic-binding protein; Alpha-pal. NRF1 ha una massa di 53.54kDa e una lunghezza di amminoacidi di 503.
Offriamo 11 anticorpi contro NRF1, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA, IP e ChIP con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.
Sommario di Entrez
This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternative splicing results in multiple transcript variants. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1.
Specificità del tessuto
Ubiquitously expressed with strongest expression in skeletal muscle.
Somiglianze di sequenza
Belongs to the NRF1/Ewg family.
Modifica post-translazionale
Phosphorylation enhances DNA binding.
Posizione cellulare
Nucleus.
