Nkx3.1 è un gene codificato dal simbolo NKX3-1. Comunemente indicato anche come: Homeobox protein Nkx-3.1; Homeobox protein NK-3 homolog A; NKX3-1; NKX3A. Nkx3.1 ha una massa di 26.35kDa e una lunghezza di amminoacidi di 234.
Offriamo 25 anticorpi contro Nkx3.1, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA, ICC/IF e ChIP con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.
Sommario di Entrez
This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this gene.
Specificità del tessuto
Highly expressed in the prostate and, at a lower level, in the testis.
Somiglianze di sequenza
Belongs to the NK-3 homeobox family.
Modifica post-translazionale
Ubiquitinated by TOPORS; monoubiquitinated at several residues and also polyubiquitinated on single residues.
Posizione cellulare
Nucleus.
