NFAT5 è un gene codificato dal simbolo NFAT5. Comunemente indicato anche come: Nuclear factor of activated T-cells 5; NF-AT5; T-cell transcription factor Tonicity-responsive enhancer-binding protein; TonE-binding protein; KIAA0827; TONEBP. NFAT5 ha una massa di 165.76kDa e una lunghezza di amminoacidi di 1531.
Offriamo 7 anticorpi contro NFAT5, allevati nel Coniglio, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano e Topo.
Informazioni su geni e proteine
Riepilogo UniProt
Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394).
Sommario di Entrez
The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene.
Specificità del tessuto
Widely expressed, with highest levels in skeletal muscle, brain, heart and peripheral blood leukocytes.
Modifica post-translazionale
Phosphorylated (PubMed:10377394). Phosphorylated at Thr-135 by CDK5 in response to osmotic stress; this phosphorylation mediates its rapid nuclear localization (PubMed:21209322).
Posizione cellulare
Nucleus. Cytoplasm.
Nuclear distribution increases under hypertonic conditions.
