Neuropeptide Y è un gene codificato dal simbolo NPY. È noto anche come Pro-NPY. Neuropeptide Y ha una massa di 10.85kDa e una lunghezza di amminoacidi di 97.
Offriamo 6 anticorpi contro Neuropeptide Y, allevati nel Coniglio, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
Sommario di Entrez
This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi.
Specificità del tessuto
One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla.
Somiglianze di sequenza
Belongs to the NPY family.
Modifica post-translazionale
The neuropeptide Y form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro).
Posizione cellulare
Secreted. Cytoplasmic vesicle > Secretory vesicle > Neuronal dense core vesicle.
