Neuroligin 1 è un gene codificato dal simbolo NLGN1. Comunemente indicato anche come: Neuroligin-1; NLGN1; KIAA1070. Neuroligin 1 ha una massa di 96.37kDa e una lunghezza di amminoacidi di 863.
Offriamo 4 anticorpi contro Neuroligin 1, allevati nel Coniglio, Topo e Capra, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep.
Sommario di Entrez
This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses.
Specificità del tessuto
Expressed in the blood vessel walls (at protein level). Detected in brain, and at lower levels in pancreas islet beta cells.
Somiglianze di sequenza
Belongs to the type-B carboxylesterase/lipase family.
Posizione cellulare
Cell membrane. Cell junction > Synapse > Postsynaptic density. Cell junction > Synapse > Synaptic cleft. Cell junction > Synapse > Synaptic cell membrane.
Enriched in synaptic plasma membranes and clustered in synaptic clefts and postsynaptic densities. Colocalized with DLG4/PSD-95 and GRIN1/NMDAR1.
