NEK7 è un gene codificato dal simbolo NEK7. Comunemente indicato anche come: Serine/threonine-protein kinase Never in mitosis A-related kinase 7; NimA-related protein kinase 7. NEK7 ha una massa di 34.55kDa e una lunghezza di amminoacidi di 302.
Offriamo 7 anticorpi contro NEK7, allevati nel Coniglio e Capra, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1.
Sommario di Entrez
NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans 'never in mitosis A' gene, which controls initiation of mitosis.
Specificità del tessuto
Highly expressed in lung, muscle, testis, brain, heart, liver, leukocyte and spleen. Lower expression in ovary, prostate and kidney. No expression seen in small intestine.
Somiglianze di sequenza
Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
Modifica post-translazionale
Phosphorylation at Ser-195 required for its activation.
Posizione cellulare
Nucleus. Cytoplasm. Cytoplasm > Cytoskeleton > Spindle pole. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome.
Present at centrosome throughout the cell cycle (PubMed:17586473). Also detected at spindle midzone of the anaphase cells and eventually concentrates at the midbody (PubMed:17586473). Interaction with ANKS3 prevents its translocation to the nucleus (By similarity).
