Nectin 2 è un gene codificato dal simbolo NECTIN2. Comunemente indicato anche come: Nectin-2; Herpes virus entry mediator B; Herpesvirus entry mediator B; Nectin cell adhesion molecule 2; Poliovirus receptor-related protein 2; NECTIN2; HVEB; PRR2; PVRL2. Nectin 2 ha una massa di 57.74kDa e una lunghezza di amminoacidi di 538.
Offriamo 10 anticorpi contro Nectin 2, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso e IP con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705). Probable cell adhesion protein (PubMed:9657005).
Sommario di Entrez
This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Specificità del tessuto
Ubiquitous.
Somiglianze di sequenza
Belongs to the nectin family.
Posizione cellulare
Cell membrane.
