NCS1 è un gene codificato dal simbolo NCS1. Comunemente indicato anche come: Neuronal calcium sensor 1; NCS-1; Frequenin homolog; Frequenin-like protein; Frequenin-like ubiquitous protein; FLUP; FREQ. NCS1 ha una massa di 21.88kDa e una lunghezza di amminoacidi di 190.
Offriamo 6 anticorpi contro NCS1, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA, ICC/IF e Citometria a Flusso con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel (By similarity).
Sommario di Entrez
This gene is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. The protein encoded by this gene regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for calmodulin. The protein is associated with secretory granules and modulates synaptic transmission and synaptic plasticity. Multiple transcript variants encoding different isoforms have been found for this gene.
Somiglianze di sequenza
Belongs to the recoverin family.
Posizione cellulare
Golgi apparatus. Cell junction > Synapse > Postsynaptic density. Cytoplasm > Perinuclear region. Cytoplasm. Cell membrane. Membrane.
Associated with Golgi stacks. Post-synaptic densities of dendrites, and in the pre-synaptic nerve terminal at neuromuscular junctions.
