NCR3 è un gene codificato dal simbolo NCR3. Comunemente indicato anche come: Natural cytotoxicity triggering receptor 3; Activating natural killer receptor p30; Natural killer cell p30-related protein; NK-p30; 1C7; LY117. NCR3 ha una massa di 21.59kDa e una lunghezza di amminoacidi di 201.
Offriamo 10 anticorpi contro NCR3, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA e Citometria a Flusso con campioni derivati da Umano e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation.
Sommario di Entrez
The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.
Specificità del tessuto
Selectively expressed by all resting and activated NK cells and weakly expressed in spleen.
Somiglianze di sequenza
Belongs to the natural cytotoxicity receptor (NCR) family.
Posizione cellulare
Cell membrane.
