NCOA4 è un gene codificato dal simbolo NCOA4. Comunemente indicato anche come: Nuclear receptor coactivator 4; NCoA-4; Androgen receptor coactivator 70 kDa protein; 70 kDa AR-activator; Androgen receptor-associated protein of 70 kDa; Ret-activating protein ELE1; ARA70; ELE1; RFG. NCOA4 ha una massa di 69.73kDa e una lunghezza di amminoacidi di 614.
Offriamo 2 anticorpi contro NCOA4, allevati nel Coniglio, che sono adatti per WB e IHC con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma.
Sommario di Entrez
This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14.
Specificità del tessuto
Widely expressed. Also detected in adipose tissues and in different cell lines. Isoform Beta is only expressed in testis.
