Myeloid leukemia factor 1 è un gene codificato dal simbolo MLF1. È noto anche come Myelodysplasia-MLF1. Myeloid leukemia factor 1 ha una massa di 30.63kDa e una lunghezza di amminoacidi di 268.
Offriamo 6 anticorpi contro Myeloid leukemia factor 1, allevati nel Coniglio e Topo, che sono adatti per WB, IHC e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
Sommario di Entrez
This gene encodes an oncoprotein which is thought to play a role in the phenotypic determination of hemopoetic cells. Translocations between this gene and nucleophosmin have been associated with myelodysplastic syndrome and acute myeloid leukemia. Multiple transcript variants encoding different isoforms have been found for this gene.
Specificità del tessuto
Most abundant in testis, ovary, skeletal muscle, heart, kidney and colon. Low expression in spleen, thymus and peripheral blood leukocytes.
Somiglianze di sequenza
Belongs to the MLF family.
Modifica post-translazionale
Phosphorylation is required for binding to YWHAZ.
Posizione cellulare
Cytoplasm. Nucleus. Cell projection > Cilium. Cytoplasm > Cytoskeleton > Cilium basal body.
Shuttles between the cytoplasm and nucleus.
