Myelin oligodendrocyte glycoprotein è un gene codificato dal simbolo MOG. Comunemente indicato anche come: Myelin-oligodendrocyte glycoprotein; MOG. Myelin oligodendrocyte glycoprotein ha una massa di 28.19kDa, una lunghezza di amminoacidi di 247, ed è implicato in Narcolepsy 7.
Offriamo 5 anticorpi contro Myelin oligodendrocyte glycoprotein, allevati nel Coniglio, Topo e Capra, che sono adatti per WB, IHC, ELISA, ICC/IF e IP con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication.
Sommario di Entrez
The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified.
Specificità del tessuto
Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes.
Coinvolgimento nella malattia
Narcolepsy 7: Neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed.
Somiglianze di sequenza
Belongs to the immunoglobulin superfamily. BTN/MOG family.
Posizione cellulare
Cell membrane.
