MVP è un gene codificato dal simbolo MVP. Comunemente indicato anche come: Major vault protein; Lung resistance-related protein; LRP. MVP ha una massa di 99.33kDa e una lunghezza di amminoacidi di 893.
Offriamo 14 anticorpi contro MVP, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ICC/IF e Citometria a Flusso con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.
Sommario di Entrez
This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene.
Specificità del tessuto
Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells.
Modifica post-translazionale
Phosphorylated on Tyr residues after EGF stimulation.
Posizione cellulare
Cytoplasm. Nucleus > Nuclear pore complex. Cytoplasm > Perinuclear region.
5% found in the nuclear pore complex (PubMed:15133037). Translocates from the nucleus to the cytoplasm upon EGF treatment (PubMed:16441665).
