MUC2 è un gene codificato dal simbolo MUC2. Comunemente indicato anche come: Mucin-2; MUC-2; Intestinal mucin-2; SMUC. MUC2 ha una massa di 540.3kDa e una lunghezza di amminoacidi di 5179.
Offriamo 19 anticorpi contro MUC2, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ICC/IF e Citometria a Flusso con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer.
Sommario di Entrez
This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Downregulation of this gene has been observed in patients with Crohn disease and ulcerative colitis.
Specificità del tessuto
Colon, small intestine, colonic tumors, bronchus, cervix and gall bladder.
Modifica post-translazionale
O-glycosylated.
Posizione cellulare
Secreted.
In the intestine, secreted into the inner and outer mucus layers.
