MST4 è un gene codificato dal simbolo STK26. Comunemente indicato anche come: Serine/threonine-protein kinase 26; MST3 and SOK1-related kinase; Mammalian STE20-like protein kinase 4; MST-4; Serine/threonine-protein kinase MASK; STK26; MASK. MST4 ha una massa di 46.53kDa e una lunghezza di amminoacidi di 416.
Offriamo 7 anticorpi contro MST4, allevati nel Coniglio e Capra, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Mediator of cell growth (PubMed:11641781, PubMed:17360971). Modulates apoptosis (PubMed:11641781, PubMed:17360971). In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006).
Sommario di Entrez
The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
Somiglianze di sequenza
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Posizione cellulare
Cytoplasm. Golgi apparatus.
Colocalized with RIPOR1 in the Golgi of serum-starved cells and relocated to cytoplasmic punctae, probably vesicular compartments, along with RIPOR1 upon serum stimulation in a Rho- and PDCD10-dependent manner (PubMed:27807006).
