MPP1 è un gene codificato dal simbolo MPP1. Comunemente indicato anche come: 55 kDa erythrocyte membrane protein; p55; Membrane protein, palmitoylated 1; DXS552E; EMP55. MPP1 ha una massa di 52.3kDa e una lunghezza di amminoacidi di 466.
Offriamo 6 anticorpi contro MPP1, allevati nel Coniglio, che sono adatti per WB, IHC e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity).
Sommario di Entrez
This gene encodes the prototype of the membrane-associated guanylate kinase (MAGUK) family proteins. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. The encoded protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 (SH3) motif, and a guanylate kinase domain. This gene product interacts with various cytoskeletal proteins and cell junctional proteins in different tissue and cell types, and may be involved in the regulation of cell shape, hair cell development, neural patterning of the retina, and apico-basal polarity and tumor suppression pathways in non-erythroid cells. Multiple transcript variants encoding different isoforms have been found for this gene.
Specificità del tessuto
Ubiquitous.
Somiglianze di sequenza
Belongs to the MAGUK family.
Modifica post-translazionale
Palmitoylated.
Posizione cellulare
Cell membrane. Cell projection > Stereocilium.
Colocalizes with WHRN at stereocilium tip during hair cell development (By similarity). Colocalizes with MPP5 in the retina, at the outer limiting membrane (OLM) (By similarity). Colocalizes with WHRN in the retina, at the outer limiting membrane (OLM), outer plexifirm layer (OPL), basal bodies and at the connecting cilium (CC) (By similarity). Colocalizes with NF2 in non-myelin-forming Schwann cells (PubMed:19144871).
