MMP8 è un gene codificato dal simbolo MMP8. Comunemente indicato anche come: Neutrophil collagenase; Matrix metalloproteinase-8; MMP-8; PMNL collagenase; PMNL-CL; CLG1. MMP8 ha una massa di 53.41kDa e una lunghezza di amminoacidi di 467.
Offriamo 8 anticorpi contro MMP8, allevati nel Coniglio, che sono adatti per WB, IHC e ELISA con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Can degrade fibrillar type I, II, and III collagens.
Sommario di Entrez
This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at different sites on this protein results in multiple active forms of the enzyme with distinct N-termini. This protein functions in the degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.
Specificità del tessuto
Neutrophils.
Somiglianze di sequenza
Belongs to the peptidase M10A family.
Posizione cellulare
Cytoplasmic granule. Secreted > Extracellular space > Extracellular matrix.
Stored in intracellular granules.
