MMP3 è un gene codificato dal simbolo MMP3. Comunemente indicato anche come: Stromelysin-1; SL-1; Matrix metalloproteinase-3; MMP-3; Transin-1; STMY1. MMP3 ha una massa di 53.98kDa, una lunghezza di amminoacidi di 477, ed è implicato in Coronary heart disease 6.
Offriamo 24 anticorpi contro MMP3, allevati nel Coniglio, Topo e Capra, che sono adatti per WB, IHC, ELISA, ICC/IF e Citometria a Flusso con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.
Sommario di Entrez
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
Coinvolgimento nella malattia
Coronary heart disease 6: A multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries.
Somiglianze di sequenza
Belongs to the peptidase M10A family.
Posizione cellulare
Secreted > Extracellular space > Extracellular matrix.
