MMP16 è un gene codificato dal simbolo MMP16. Comunemente indicato anche come: Matrix metalloproteinase-16; MMP-16; MMP-X2; Membrane-type matrix metalloproteinase 3; MT-MMP 3; Membrane-type-3 matrix metalloproteinase; MT3-MMP; C8orf57; MMPX2. MMP16 ha una massa di 69.52kDa e una lunghezza di amminoacidi di 607.
Offriamo 6 anticorpi contro MMP16, allevati nel Coniglio, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.
Sommario di Entrez
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein activates MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16.
Specificità del tessuto
Expressed in heart, brain, placenta, ovary and small intestine. Isoform Short is found in the ovary.
Somiglianze di sequenza
Belongs to the peptidase M10A family.
Modifica post-translazionale
The precursor is cleaved by a furin endopeptidase.
Posizione cellulare
Cell membrane.
Localized at the cell surface of melanoma cells.
