MMP12 è un gene codificato dal simbolo MMP12. Comunemente indicato anche come: Macrophage metalloelastase; MME; Macrophage elastase; ME; Matrix metalloproteinase-12; MMP-12; HME. MMP12 ha una massa di 54kDa e una lunghezza di amminoacidi di 470.
Offriamo 10 anticorpi contro MMP12, allevati nel Coniglio e Capra, che sono adatti per WB, IHC, ELISA, ICC/IF e Citometria a Flusso con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
Sommario di Entrez
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease degrades soluble and insoluble elastin. This gene may play a role in aneurysm formation and mutations in this gene are associated with lung function and chronic obstructive pulmonary disease (COPD). This gene is part of a cluster of MMP genes on chromosome 11.
Specificità del tessuto
Found in alveolar macrophages but not in peripheral blood monocytes.
Somiglianze di sequenza
Belongs to the peptidase M10A family.
Posizione cellulare
Secreted > Extracellular space > Extracellular matrix.
